Resolving sub-clonal heterogeneity within cell-line growths by single cell sequencing genomic DNA
Enrique I. Velazquez-Villarreal, Shamoni Maheshwari, Jon M. Sorenson, Ian T. Fiddes, Vijay Kumar, Yifeng Yin, Michelle G. Webb, Claudia Catalanotti, Mira Grigorova, Paul A. Edwards, John David Carpten, David Wesley Craig
The paper uses single-cell sequencing of genomic DNA to resolve sub-clonal heterogeneity in the COLO829 cell line, identifying four major sub-clones and explaining conflicting bulk sequencing results.
bioRxiv · Sep 5, 2019 · PreprintGenomics