Michelle G. Webb

This study uses single-cell whole genome sequencing and spatial transcriptomics to uncover intra-tumoral heterogeneity in ovarian cancer, revealing evolutionary relationships and functionally consequential copy number alterations.

The paper constructs an integrated atlas of astrocytes from human and mouse neurodegenerative disease models, identifying conserved and divergent subtypes across species.

The paper presents a multi-layered molecular dataset from iPSC-derived dopaminergic neurons to model Parkinson's disease genetic risk and provides a data browser for accessing these resources.

The paper uses single-cell sequencing of genomic DNA to resolve sub-clonal heterogeneity in the COLO829 cell line, identifying four major sub-clones and explaining conflicting bulk sequencing results.