Decoding Spatial Programs in Human Glioblastoma Through Surprisal Information-Theoretical Analysis
Shuozhen Bao, Gretchen Long, Shouryo Ghose, N.-K. Wang, Haikuo Li, Mei Zhong, Logan Carter Matthews, Yao Lu, Jie Sheng, Zewei Tu, William Escobar, Pallavi P. Gopal, Declan McGuone, Zeynep Erson-Omay, Khaled Alok, , Rong Fan
This paper uses surprisal information-theoretic analysis on spatial transcriptomic data from human glioblastoma to uncover hidden spatial programs and interactions not detected by standard methods.
bioRxiv · Jun 24, 2026 · PreprintSystems Biology