Pallavi P. Gopal

The paper shows that alpha-synuclein phase separation can form Lewy body-like structures without pre-existing seeds, suggesting a new mechanism for neurodegeneration.

The paper identifies a distinct receptor-bound amyloid-β filament conformation in Alzheimer's disease brain that interacts with prion protein and causes synaptic damage.

This paper uses surprisal information-theoretic analysis on spatial transcriptomic data from human glioblastoma to uncover hidden spatial programs and interactions not detected by standard methods.

This paper develops a light-activated platform for isolating and fractionating lipid-based nanovesicles with high purity and scalability.

The paper performs single-cell transcriptomic and proteomic analysis of Parkinson's disease brains, identifying cell-type-specific changes and differences from Alzheimer's disease.

This study uses in-silico methods to design α-helical peptides that inhibit TDP-43 aggregation, identifying candidates with stable structures and high binding affinity for pathological filaments.

This study shows that WIPI2B expression counteracts age-related decline in autophagosome biogenesis in neurons, suggesting it as a therapeutic target for age-associated neurodegeneration.