Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration
Marco Leibinger, Charlotte Zeitler, Miriam Paulat, Philipp Gobrecht, Alexander M. Hilla, Anastasia Andreadaki, Rainer Guthoff, Dietmar Fischer
The paper shows that parthenolide, by inhibiting microtubule detyrosination, enhances axon regeneration in the CNS when combined with pro-regenerative treatments like hIL-6.
eLife · Jul 5, 2023Peer-reviewedNeuroscience