A conserved glycan motif overcomes antigenic variation inducing broadly reactive antibodies against the zoonotic pathogen Streptococcus suis
Yao Shi, Göran Widmalm, Charlotte Sorieul, Thomas J. Roodsant, Jeffrey S. Rush, Natalia Korotkova, Antonius A. C. Jacobs, Mirlin P. Spaninks, Ries Grommen, C. Coral Domínguez-Medina, Irene M. Schimmel, Nicole N. van der Wel, Cameron W. Kenner, Christian Heiß, Parastoo Azadi, , Nina M. van Sorge
This study identifies a conserved glycan motif in Streptococcus suis that elicits broadly reactive antibodies, suggesting it as a target for next-generation vaccines.
bioRxiv · Jun 2, 2025 · PreprintMicrobiology