Parastoo Azadi

N-glycoproteomic profiling of the hookworm Ancylostoma ceylanicum reveals heterogeneity and phosphorylcholine-modified glycans in larval and adult parasites.

This study performs N-glycoproteomic profiling of Ancylostoma ceylanicum, identifying stage-specific glycoproteins and phosphorylcholine-modified glycans in larval and adult parasites.

Identification of glycosyltransferases that synthesize pectin heteroglycan block polymers and a structural motif required for their activity

This paper identifies GAUT13 and GAUT14 as enzymes that synthesize RG-I:HG heteroglycans and reveals a motif enabling functional domain swapping in glycosyltransferases.

Genome-wide characterization of host factors involved in single-stranded RNA and DNA phage infection pathways

This study identifies host factors critical for ssRNA and ssDNA phage infection in E. coli, revealing conserved dependencies and lineage-specific requirements.

Transposon insertion sequencing of Pseudomonas aeruginosa identifies multiple intersecting pathways essential for extreme colistin resistance

This study identifies 13 genes essential for extreme colistin resistance in Pseudomonas aeruginosa using transposon insertion sequencing and validates novel pathways contributing to resistance.

Autoantibodies from recovered Guillain-Barre syndrome patients exhibit altered effector functions that prevent subsequent neuron degeneration

This study shows that some GBS patients retain anti-ganglioside antibodies years after recovery, which no longer damage neurons but may still offer protection against C. jejuni.

Enterococcus faecalis autolysin, EpaU, binds the enterococcal polysaccharide antigen via its teichoic acid-like repeats and modulates c-di-AMP signaling

This study identifies EpaU as an autolysin that binds the enterococcal polysaccharide antigen and modulates c-di-AMP signaling, affecting antibiotic resistance and cell turgor in Enterococcus faecalis.

Persistent trade-offs balance competition and colonization across centuries

The paper shows a trade-off between competitive ability and host colonization in Pseudomonas populations has persisted for centuries.

Multi-factorial regulatory networks of placental antibody transfer by Fc receptors and maternal IgG Fc characteristics are modulated by clinical covariate profiles

The paper identifies multi-factorial regulatory networks governing placental antibody transfer, showing how Fc receptor expression, IgG subclass, and clinical covariates interact to influence transfer efficiency.

Ctenophore mesoglea is composed of mucins and novel polysaccharides

This study identifies mucin-related proteins and novel sulfated polysaccharides as the main components of ctenophore mesoglea, revealing differences in ECM physiology compared to other metazoans.

Mass Spectrometric Determination of Site-Specific O-Acetylation in Rhamnogalacturonan-I Oligomers

This paper develops a method to determine site-specific O-acetylation in RG-I oligomers using deuterated acetyl groups and tandem mass spectrometry.

Arabidopsis GALACTURONOSYLTRANSFERASE (GAUT) 1 synthesizes a homogalacturonan tightly bound to the cell wall and required for cell expansion

This paper shows GAUT1 synthesizes HG in Arabidopsis, which is tightly bound to the cell wall and essential for cell expansion.

Gram-positive bacterial cell wall components inhibit herpes simplex virus infection.

This study identifies gram-positive bacterial cell wall components, such as peptidoglycan and lipoteichoic acid, as inhibitors of HSV-1 and HSV-2 infection in vitro and in a mouse model.

Deep structural analysis of rhamnogalacturonan-I (RG-I) in Arabidopsis reveals new insights into pectin diversity

The paper provides a detailed structural analysis of rhamnogalacturonan-I in Arabidopsis, revealing novel structural features including O-acetylation of rhamnose residues.

The role of pigments in light color variation of the firefly Photinus pyralis

The paper investigates whether pigments contribute to light color variation in fireflies, finding that ommochrome and pterin pigments may filter luciferase light but no significant gene expression differences were found between color variants.

A conserved glycan motif overcomes antigenic variation inducing broadly reactive antibodies against the zoonotic pathogen Streptococcus suis

This study identifies a conserved glycan motif in Streptococcus suis that elicits broadly reactive antibodies, suggesting it as a target for next-generation vaccines.

Hyper-Glycosylation as a Central Metabolic Driver of Alzheimers Disease

This study identifies hyper-glycosylation as a driver of Alzheimer's disease through metabolic analysis and interventions, showing its impact on cognitive decline and mortality.

Recognition of unique cell surface glycopolymers by diversified lectin domains specifies umbrella toxin targeting

The paper identifies teichuronic acid oligosaccharides as the receptor for umbrella toxins and shows targeting specificity arises from lectin domain recognition of variable TUA-WTA structures.

Glycoengineering of the hepatitis C virus E2 glycoprotein leads to improved biochemical properties and enhanced immunogenicity

This study shows that glycoengineering of HCV E2 glycoprotein affects antigen biochemical properties and immune response, with some glycans improving neutralization potency.

Structure and mechanism of biosynthesis of Streptococcus mutans cell wall polysaccharide

This study identifies the structure and biosynthesis mechanism of Streptococcus mutans cell wall polysaccharide, revealing key modifications and their roles in bacterial morphology and biofilm formation.

Identification of the Regulatory Elements and Protein Substrates of Lysine Acetoacetylation

The paper identifies regulatory elements and protein substrates of lysine acetoacetylation, revealing its role in cellular processes and epigenetic regulation.

Discovery of a single-subunit oligosaccharyltransferase that enables glycosylation of full-length IgG antibodies in Escherichia coli

The paper identifies a single-subunit oligosaccharyltransferase from Desulfovibrio marinus that enables glycosylation of full-length IgG antibodies in E. coli.