Nicole N. van der Wel

The paper identifies pks12 as an in vivo essential gene in Mtb by combining genomic, metabolomic, and phenotypic analyses, revealing its role in mycolyl lipid synthesis and host-pathogen interface structure.

This study shows that chronic low-concentration PM2.5 exposure after ischemic injury accelerates CKD through mitochondrial dysfunction and lysosomal stress, with nicotinamide reversing some effects.

This study shows that microtubule detyrosination in HCM causes nuclear shape changes and YAP1 signaling, which can be reversed by inhibiting detyrosination.

This study identifies a conserved glycan motif in Streptococcus suis that elicits broadly reactive antibodies, suggesting it as a target for next-generation vaccines.

This paper identifies SLC25A23 as a vulnerability in senescent cancer cells and shows that salinomycin induces immunogenic cell death, enhancing immune destruction of these cells when combined with a DR5 agonistic antibody.

This study identifies IFT74 variants causing skeletal ciliopathy and motile cilia defects in humans and mice, revealing functional differences between motile and primary cilia.