Ire1 membrane stress responses support cell growth upon disruptions in inter-organelle contacts
Bailey RW Hewlett, Bianca M. Esch, Ffion B. Thomas, Misako Araki, Atsuko Ikeda, Kazuki Hanaoka, Kouichi Funato, Florian Fröhlich, Christopher J. Stefan
This study shows that Ire1-dependent Membrane Stress Responses (MSR) help yeast cells grow when inter-organelle contacts are disrupted by compensating for lipid metabolism defects and modulating Ca2+ signaling.
bioRxiv · Jul 31, 2026 · PreprintCell Biology