High efficiency organoid-derived cyst cultures as a drug discovery platform for polycystic kidney disease
Thitinee Vanichapol, Ruby Wangford, Misao Takemoto, Motonari Uesugi, Alan James Davidson, Veronika Sander
The paper describes a scalable method to generate cystic ureteric bud organoids from PKD2-deficient hPSCs for ADPKD drug discovery, identifying a nutrient conjugate that reduces cyst formation.
bioRxiv · Feb 16, 2025 · PreprintMolecular Biology