Author

Motonari Uesugi

Kyoto UniversityORCID 0000-0002-8515-445XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Akiyuki NishimuraiD· 1 shared Alan James DavidsoniD· 1 shared Alexandra BoylingiD· 1 shared Anthony N. CutrupiiD· 1 shared Bianca Rose GrosziD· 1 shared Brent NeumanniD· 1 shared Di MaoiD· 1 shared Garth A. NicholsoniD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperPharmacology & Toxicology

Akiyuki NishimuraORCID

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3 papers

Recent·Most cited

Lipid A counteracts doxorubicin-induced systemic dysfunction by boosting mitochondrial activity

Yuga Nakaguma, Yuri Kato, Yara Atef, Tomoya Ito, Akiyuki Nishimura, Motonari Uesugi, Yasunari Kanda, Jun Kunisawa, Motohiro Nishida

This study shows lipid A improves mitochondrial function and counteracts doxorubicin-induced heart failure and immune decline in mice.

bioRxiv · Apr 21, 2026 · PreprintPharmacology & Toxicology

High efficiency organoid-derived cyst cultures as a drug discovery platform for polycystic kidney disease

Thitinee Vanichapol, Ruby Wangford, Misao Takemoto, Motonari Uesugi, Alan James Davidson, Veronika Sander

The paper describes a scalable method to generate cystic ureteric bud organoids from PKD2-deficient hPSCs for ADPKD drug discovery, identifying a nutrient conjugate that reduces cyst formation.

bioRxiv · Feb 16, 2025 · PreprintMolecular Biology

Novel gene-intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy: A new mechanism for motor neuron degeneration.

Anthony N. Cutrupi, Ramesh K. Narayanan, Gonzalo Pérez‐Siles, Bianca Rose Grosz, Kaitao Lai, Alexandra Boyling, Melina Ellis, Ruby C.Y. Lin, Brent Neumann, Di Mao, Motonari Uesugi, Garth A. Nicholson, Steve Vucic, Mario Saporta, Marina L. Kennerson

The paper identifies a novel gene-intergenic fusion in UBE3C causing dHMN and demonstrates its pathogenic effects using patient-derived models and a C. elegans transgenic system.

bioRxiv · Aug 16, 2022 · PreprintNeuroscience