Precision Aptamers Against a Native GPCR through Ligand-Guided Selection
Agbor Vydaline, Mitali Bhate, Divyani Sitaldin, Yilam Ng Cen, Sergei Rozhkov, German Sosa, Amédée des Georges, Prabodhika R. Mallikaratchy
This paper introduces a ligand-guided selection method to discover aptamers specific to GPCRs in their native membrane context, showing they bind selectively to cell-surface receptors and induce internalization.
bioRxiv · May 7, 2026 · PreprintBiochemistry