Amédée des Georges

This study identifies the RY12 domain of RyR1 as an ADP sensor and reveals dantrolene's binding mechanism through cryo-EM structures.

This paper reports the cryo-EM structure of a TrkA-neutralizing antibody complex, revealing its mechanism of isoform selectivity and therapeutic potential for chronic pain.

This paper introduces a ligand-guided selection method to discover aptamers specific to GPCRs in their native membrane context, showing they bind selectively to cell-surface receptors and induce internalization.

The paper determines the structure of crustacyanin complexes in American lobster carapace, revealing how HPR proteins contribute to blue coloration through structural tuning of astaxanthin absorption.

The paper reveals how beta-arrestin 1 activates Src kinase via two distinct SH3 domain interactions, using cryo-EM to show structural mechanisms of beta-arrestin-mediated signaling.

This paper reviews deep learning methods for automating atomic model building in cryo-EM density maps, discussing their classification, limitations, and future directions.

This study uses structural models to clarify DHX29's role in mRNA scanning, showing it transiently pulls mRNA opposite to scanning direction.

This paper identifies NRP1 as a co-receptor for NGF and TrkA pain signaling and shows that targeting NRP1 or GIPC1 can reduce chronic pain without opioid use.