Genetically-programmed Hypervesiculation of Lactiplantibacillus plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model
Nicholas H. Pirolli, Daniel H. Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Samantha C. Reus, William E. Bentley, , Steven M. Jay
This study genetically engineers Lactiplantibacillus plantarum to produce 66-fold more extracellular vesicles, which show superior therapeutic efficacy in a mouse model of inflammatory bowel disease.
Advanced Science · Nov 26, 2025Peer-reviewedBioengineering