BioengineeringAdvanced SciencePeer-reviewed
Genetically-programmed Hypervesiculation of Lactiplantibacillus plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model
Nicholas H. Pirolli, Daniel H. Levy, Alyssa Schledwitz…·Steven M. Jay
This study genetically engineers Lactiplantibacillus plantarum to produce 66-fold more extracellular vesicles, which show superior therapeutic efficacy in a mouse model of inflammatory bowel disease.
10 citations