ACE1 knockout in neurons selectively dysregulates the hippocampal renin angiotensin system and causes vascular loss
Sohee Jeon, Miranda A. Salvo, Alia O. Alia, Jelena Popović, Mitchell Zagardo, Sidhanth Chandra, Malik M. Nassan, David Gate, Robert J. Vassar, Leah K. Cuddy
This study shows that neuronal ACE1 knockout in mice causes hippocampal RAS dysregulation and vascular loss without affecting motor skills.
bioRxiv · Feb 21, 2024 · PreprintNeuroscience