Author

Sidhanth Chandra

Northwestern UniversityORCID 0000-0002-9866-2525Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Robert J. VassariD· 2 shared Alia O. AliaiD· 1 shared Alyssa Klop· 1 shared Ammaarah W. Khatri· 1 shared Andrew B. WestiD· 1 shared Aneesh Pathak· 1 shared Arpine SokratianiD· 1 shared Ashley S. HarmsiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Robert J. VassarORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Neuronal overexpression of Nrf2 reduces dystrophic neurites in 5XFAD Alzheimer's disease model mice

Katherine R. Sadleir, Karen P Gomez, Sidhanth Chandra, Makenna L. Ley, Ammaarah W. Khatri, Joanna Guo, Yunlu Xue, Constance L. Cepko, Robert J. Vassar

This study shows neuronal overexpression of Nrf2 reduces dystrophic neurites in 5XFAD mice by lowering BACE1 and other proteins in these structures.

Alzheimer s Research & Therapy · Jun 3, 2026Peer-reviewedNeuroscience

ACE1 knockout in neurons selectively dysregulates the hippocampal renin angiotensin system and causes vascular loss

Sohee Jeon, Miranda A. Salvo, Alia O. Alia, Jelena Popović, Mitchell Zagardo, Sidhanth Chandra, Malik M. Nassan, David Gate, Robert J. Vassar, Leah K. Cuddy

This study shows that neuronal ACE1 knockout in mice causes hippocampal RAS dysregulation and vascular loss without affecting motor skills.

bioRxiv · Feb 21, 2024 · PreprintNeuroscience

14-3-3s reduce propagation and toxicity of pathologic alpha-synuclein in the in vivo preformed fibril model

Rachel Underwood, Mary A. Gannon, Aneesh Pathak, Navya Kapa, Sidhanth Chandra, Alyssa Klop, Talene A. Yacoubian

This study shows that 14-3-3{theta} reduces alpha-synuclein toxicity and aggregation in an in vivo preformed fibril model, improving behavioral and neuronal outcomes.

bioRxiv · Nov 17, 2020 · PreprintNeuroscience

Pathologic α-Synuclein Species Activate LRRK2 in Pro-Inflammatory Monocyte and Macrophage Responses

Enquan Xu, Ravindra Boddu, Hisham Abdelmotilib, Kaela Kelly, Arpine Sokratian, Ashley S. Harms, Aubrey M Schonhoff, Nicole Bryant, Irene E. Harmsen, Michael G. Schlossmacher, Sidhanth Chandra, Valentina Krendelshchikova, Zhiyong Liu, Andrew B. West

The paper shows that α-synuclein fibrils activate LRRK2 kinase in monocyte-derived macrophages, linking LRRK2 mutations to pro-inflammatory responses in Parkinson's disease.

bioRxiv · May 4, 2020 · PreprintNeuroscience