Author

Leah K. Cuddy

Northwestern UniversityORCID 0000-0002-6764-3065Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:scRNA-seq· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Alia O. AliaiD· 2 shared Jelena PopovićiD· 2 shared Robert J. VassariD· 2 shared Sohee JeoniD· 2 shared David GateiD· 1 shared Malik M. NassaniD· 1 shared Miranda A. SalvoiD· 1 shared Mitchell Zagardo· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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2 shared papersNeuroscience

Alia O. AliaORCID

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2 papers

Recent·Most cited

ACE1 Does Not Influence Cerebral Aβ Degradation or Amyloid Plaque Accumulation in 5XFAD Mice

Sohee Jeon, Alia O. Alia, Jelena Popović, Robert J. Vassar, Leah K. Cuddy

This study investigates whether ACE1 influences Aβ degradation or amyloid plaque accumulation in 5XFAD mice, finding no effect on amyloid burden or neuroinflammation.

PLoS ONE · Sep 15, 2025Peer-reviewedNeuroscience

ACE1 knockout in neurons selectively dysregulates the hippocampal renin angiotensin system and causes vascular loss

Sohee Jeon, Miranda A. Salvo, Alia O. Alia, Jelena Popović, Mitchell Zagardo, Sidhanth Chandra, Malik M. Nassan, David Gate, Robert J. Vassar, Leah K. Cuddy

This study shows that neuronal ACE1 knockout in mice causes hippocampal RAS dysregulation and vascular loss without affecting motor skills.

bioRxiv · Feb 21, 2024 · PreprintNeuroscience