SFPQ-TFE3 gene fusion reciprocally regulates mTORC1 activity and induces lineage plasticity in a novel mouse model of renal tumorigenesis
Kaushal V. Asrani, Adrianna Amaral de Aragao Mendes, Juhyung Woo, Sanaz Nourmohammadi Abadchi, Thiago Vidotto, Eddie L. Imada, Alyza M. Skaist, Kewen Feng, Hans B. Liu, Mithila Kasbe, Yorifumi Satou, Masaya Baba, Yuichi Oike, Patricia Outeda, Terry J. Watnick, , Tamara Levin Lotan
This study creates a mouse model of SFPQ-TFE3-driven renal tumors and shows it induces lineage plasticity through mTORC1 activation.
Nature Communications · Oct 3, 2025Peer-reviewedCancer Biology