Enhancing viscosity control in antibody formulations: A framework for the biophysical screening of mutations targeting solvent-accessible hydrophobic and electrostatic patches
Georgina Bethany Armstrong, Vidhi Shah, Paula Sanches, Mitul K. Patel, Ricky Casey, Craig Jamieson, Glenn A. Burley, William Lewis, Zahra Rattray
This study presents a framework for computationally screening mutations to modify antibody viscosity, showing that hydrophobic and electrostatic patches significantly affect viscosity, with positive charges causing the most increase.
Computational and Structural Biotechnology Journal · May 24, 2024Peer-reviewedBioengineering