Inactivation of HIF-P4H-1 Stabilizes IKKα, Modulates Non-Canonical NF-κB Signaling, and Sensitizes Cancer Cells to Cell Death
Karim Ullah, Mizanur Rahman, Farhan Quadir, Valerio Izzi, Ulrich Bergmann, Jing Zhang, Qing Zhang, Rongxue Wu, Joni M. Mäki, Johanna Myllyharju
This study identifies HIF-P4H-1 as a regulator of non-canonical NF-κB signaling by stabilizing IKKα and shows its inhibition sensitizes cancer cells to death.
bioRxiv · Jul 20, 2026 · PreprintCancer Biology