Valerio Izzi

Inactivation of HIF-P4H-1 Stabilizes IKKα, Modulates Non-Canonical NF-κB Signaling, and Sensitizes Cancer Cells to Cell Death

This study identifies HIF-P4H-1 as a regulator of non-canonical NF-κB signaling by stabilizing IKKα and shows its inhibition sensitizes cancer cells to death.

ECMME: an atlas of selection pressures on the mammalian extracellular matrix reveals contrasting evolutionary dynamics

The paper analyzes selection pressures on mammalian extracellular matrix proteins across species and develops an open-access browser to visualize evolutionary dynamics.

NaVis: a virtual microscopy framework for interactive histological interrogation of spatial transcriptomics data

NaVis provides an interactive virtual microscopy framework for analyzing spatial transcriptomics data by integrating gene expression with histological morphology.

cran2crux: automatically create CRUX ports for R-packages

cran2crux automatically generates CRUX ports for R packages, simplifying their integration with the CRUX package manager.

MatriSpace: Identification and visualization of spatially resolved ECM gene expression patterns in health and disease

MatriSpace identifies and visualizes spatial ECM gene expression patterns in health and disease using spatial transcriptomics data.

P4HA3 is abundantly expressed during early embryonic development, but does not catalyze the formation of 4-hydroxyproline in type I collagen

Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early adaptation to mechanical loading in the human muscle-tendon unit

The paper identifies spatially distinct fibroblast and myonuclei subtypes in human muscle-tendon units that respond to mechanical loading by remodeling the extracellular matrix.

MatriCom: a scRNA-Seq data mining tool to infer ECM-ECM and cell-ECM communication systems

MatriCom mines scRNA-Seq datasets to infer ECM-ECM and cell-ECM communication systems across diverse cell populations.

ProToDeviseR: an automated protein topology scheme generator

ProToDeviseR automatically generates protein topology schemes from sequence data or prediction results, integrating features from multiple resources into publication-ready formats.

Tumour-derived LAMA5 is critical for tumour initiation and controls progression and phenotype in luminal breast cancer

This study shows LAMA5 is essential for luminal breast cancer initiation and progression, with Fgf signaling playing a key role in its effects.

Mycolic acid and cholesterol induced transcriptomic adaptations in wild type and Mce complex ATPase subunit deleted strain of M. tuberculosis H37Rv

This study compares transcriptomic responses of wild type and mkl-deleted M. tuberculosis strains to cholesterol and mycolic acid, revealing differential gene expression patterns and insights into adaptation strategies.

Matrisome AnalyzeR: A suite of tools to annotate and quantify ECM molecules in big datasets across organisms

Matrisome AnalyzeR provides tools to annotate and quantify extracellular matrix molecules in large datasets across organisms.

Collagen prolyl 4-hydroxylases have sequence specificity towards different X-Pro-Gly triplets

This study identifies sequence specificity of collagen prolyl 4-hydroxylase isoenzymes for different X-Pro-Gly triplets and their impact on collagen stability and assembly.

Temporally and Spatially Regulated Collagen XVIII Isoforms Impact Ureteric Patterning Through Their TSP1-like Domain

This study shows that specific collagen XVIII isoforms regulate ureteric branching morphogenesis through their TSP1-like domain in kidney development.