Novel Fas-TNFR chimeras that prevents Fas ligand-mediated kill and signals synergistically to enhance CAR T-cell efficacy
Callum McKenzie, Mohamed El-Kholy, Farhaan Parekh, Mathew P. Robson, Katarina Lamb, Christopher G. Allen, James Sillibourne, Shaun P Cordoba, Simon Thomas, Martin A. Pulè
This study identifies Fas-CD40 as a chimeric Fas-TNFR that prevents Fas ligand-mediated kill and enhances CAR T-cell efficacy through synergistic signaling.
Molecular Therapy — Nucleic Acids · Apr 25, 2023Peer-reviewedSynthetic Biology