Author

Farhaan Parekh

Autolus (United Kingdom)ORCID 0000-0002-3652-0855Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

Christopher G. AlleniD· 2 shared James SillibourneiD· 2 shared Katarina LambiD· 2 shared Martin A. PulèiD· 2 shared Shaun P CordobaiD· 2 shared Simon ThomasiD· 2 shared Abigail Dolor· 1 shared Alastair HotblackiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Christopher G. AllenORCID

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2 papers

Recent·Most cited

Designer small molecule control system based on Minocycline induced disruption of protein-protein interaction.

Ram Jha, Alexander Kinna, Alastair Hotblack, Reyisa Bughda, Anna M. Bulek, Isaac Gannon, F. Tudor Ilca, Christopher G. Allen, Katarina Lamb, Abigail Dolor, Ian Scott, Farhaan Parekh, James Sillibourne, Shaun P Cordoba, Shimobi C. Onuoha, , Martin A. Pulè

The paper develops a small-molecule control system using minocycline to disrupt protein-protein interactions for reversible and dose-dependent control of therapeutic applications.

ACS Chemical Biology · Jan 20, 2024Peer-reviewedMolecular Biology

Novel Fas-TNFR chimeras that prevents Fas ligand-mediated kill and signals synergistically to enhance CAR T-cell efficacy

Callum McKenzie, Mohamed El-Kholy, Farhaan Parekh, Mathew P. Robson, Katarina Lamb, Christopher G. Allen, James Sillibourne, Shaun P Cordoba, Simon Thomas, Martin A. Pulè

This study identifies Fas-CD40 as a chimeric Fas-TNFR that prevents Fas ligand-mediated kill and enhances CAR T-cell efficacy through synergistic signaling.

Molecular Therapy — Nucleic Acids · Apr 25, 2023Peer-reviewedSynthetic Biology