Pharmacology & ToxicologybioRxivPreprint
Oncoprotein GT198 is a direct target of taxol
Zheqiong Yang, Vadim J. Gurvich, Mohan L. Gupta…·Lan Ko
This study identifies GT198 as a direct target of taxol, showing it binds to GT198's DNA-binding domain and inhibits its function, which may explain taxol's efficacy and side effects in cancer treatment.
DOI 10.1101/675579