The widely used Ucp1-CreEvdr transgene elicits complex developmental and metabolic phenotypes.
Manasi Suchit Halurkar, Oto Inoue, Rajib Mukherjee, Christian Louis Bonatto Paese, Molly Duszynski, Samantha A. Brugmann, Hee‐Woong Lim, Joan Sánchez-Gurmaches
The paper analyzes the Ucp1-CreEvdr transgenic mouse line and finds it causes complex developmental and metabolic issues independent of its intended genetic manipulation.
bioRxiv · Oct 20, 2023 · PreprintMolecular Biology