Hee‐Woong Lim

This study uses CRISPR-mediated lineage tracing to show that adipose depot identity is shaped by anatomical niche rather than embryonic lineage.

This study shows that HNF4A maintains proximal tubule identity in adult mouse kidneys and its loss leads to injury-associated gene activation and loss of mature epithelial features.

The paper shows that PRDM1 collaborates with pioneer TFs to enhance enhancer repression during human endoderm differentiation, preserving lineage fidelity through hyper-bivalent enhancers.

This study shows that HNF1B is essential for maintaining proximal tubule identity in mature kidney cells and prevents activation of alternative nephron segment programs.

This study identifies circadian regulation of intestinal epithelial cell differentiation through NOTCH/Hes1 oscillations in mouse enteroids.

This study shows that constitutive Yap activation in distal nephron segments disrupts epithelial identity and nephron patterning by altering cell proliferation, lineage boundaries, and gene expression.

The paper identifies epithelial cell-state transitions linked to disease severity in pediatric eosinophilic esophagitis using single-cell and bulk transcriptomic data.

The paper generates a knock-in Six2Cre mouse line to study nephron progenitor potential, finding a transient contribution to the renal interstitium around embryonic day 11.

This study uses scRNA-seq to show that Tcf21 is essential for Foxd1+ stromal progenitor differentiation during kidney development, with loss of Tcf21 causing stromal subpopulation depletion and emergence of Emcn-expressing cells.

This study shows PRDM16 maintains SMC identity and regulates atherosclerotic plaque composition by inhibiting synthetic gene programs during SMC fate switching.

This study shows that epithelial nitric oxide synthase 2 (Nos2) influences host-microbiota interactions in IBD by regulating intestinal nitrates and nitrate-metabolizing bacteria, with implications for disease management.

The paper shows that MAPK/ERK signaling prevents H3K9me3 heterochromatin formation at lineage-specific gene loci during mesoderm and endoderm differentiation from human pluripotent stem cells.

The paper identifies thin descending limb cells in developing mouse kidneys using scRNA-seq and shows they originate from proximal tubule cells, with Hnf4a playing a role in their development.

The paper analyzes the Ucp1-CreEvdr transgenic mouse line and finds it causes complex developmental and metabolic issues independent of its intended genetic manipulation.

This study identifies Hedgehog signaling as critical for maintaining mesenchymal nephron progenitors by inhibiting Notch signaling and upregulating Fox factors.

This study shows prenatal stress causes sex-specific behavioral and neuroendocrine issues in mice, with maternal care reversing some effects.

The paper identifies how flanking nucleotides influence CEBP binding and transcriptional activity, revealing sequence biases and heterodimerization effects in mammalian bZip TFs.