Biofilm-Derived Curli and Z-DNA Shape Anti-DNA Antibody Responses During Salmonella Infections
Molly Elkins, Kaitlyn C. M. Grando, Courtney Covolo, Diane M Spencer, Jacob F. Maziarz, Erin M. Vasicek, Carly DeAntoneo, Francisco Javier Albicoro, Shingo Bessho, Zachary Reichenbach, Sophia Olubajo, Bettina A. Buttaro, Siddharth Balachandran, John S. Gunn, David S. Pisetsky, Çağla Tükel
This study shows that Salmonella biofilms contain Z-DNA, which triggers anti-Z-DNA antibody responses in mice, linking bacterial infections and biofilm formation to autoimmune disease.
PLoS Pathogens · Jul 14, 2026Peer-reviewedImmunology