Siddharth Balachandran

This study shows that highly pathogenic coronaviruses induce necroptosis, leading to lung injury, and that inhibiting necroptosis reduces disease severity in mice.

This study compares Z22 and Z-D11 antibodies' binding to Z-NA substrates, finding they have distinct specificities and functional capabilities.

This study shows that Salmonella biofilms contain Z-DNA, which triggers anti-Z-DNA antibody responses in mice, linking bacterial infections and biofilm formation to autoimmune disease.

The paper presents cryo-EM structures of anti-Z-DNA antibodies bound to Z-DNA, revealing their recognition mechanism and lack of B-to-Z transition induction.

This study shows that RIPK1 is essential for ZBP1-dependent necroptosis in human cells but not in mice, highlighting a species-specific mechanism.