Label-free characterisation of amyloids and alpha-Synuclein polymorphs by exploiting their intrinsic fluorescence property
Chyi Wei Chung, Amberley D. Stephens, Edward Ward, Yuqing Feng, Molly Jo Davis, Clemens F. Kaminski, Gabriele S. Kaminski Schierle
This paper introduces a label-free method using intrinsic fluorescence lifetime to characterize amyloids and their polymorphs, showing distinct fluorescence lifetimes for different amyloid structures and polymorphic populations.
Analytical Chemistry · Mar 25, 2022Peer-reviewedMolecular Biology