Chyi Wei Chung

This study shows that spatial separation of Aurora B from the outer kinetochore regulates MPS1 recruitment and SAC signaling during mitosis.

The paper determines the structure of the chromosomal passenger complex targeting module bound to phosphorylated nucleosomes, revealing a pivot-tether mechanism for Aurora B localization.

This study investigates how monomeric and fibrillar alpha-synuclein interact with synaptic vesicles, showing fibrils disintegrate vesicles and increase neuronal uptake, potentially contributing to Parkinson's disease pathology.

The paper develops a multiplex reverse genetics platform to identify genetic modifiers of protein misfolding in neurodegenerative diseases and identifies DNAJB6 as a modifier of toxicity and solubility of ALS/FTD-linked RNA-binding proteins.

This paper introduces a label-free method using intrinsic fluorescence lifetime to characterize amyloids and their polymorphs, showing distinct fluorescence lifetimes for different amyloid structures and polymorphic populations.