An Aged Microenvironment Increases CAR T Cell Cytotoxicity but Impairs Therapeutic Efficacy
Mona Kabha, Noy Rosenzweig, akmaral Rakhymzhanova, Orna Atar, Cyrille J. Cohen, Noga Ron‐Harel
This study shows that aging affects CAR T cell production and function, leading to reduced therapeutic efficacy in elderly hosts.
bioRxiv · May 4, 2025 · PreprintImmunology