Orna Atar

Haem toxicity in the aged spleen impairs T-cell immunity through iron deprivation

This study shows that haem toxicity in the aged spleen impairs T-cell immunity through iron deprivation, and iron infusions can enhance vaccination responses in aged mice.

An Aged Microenvironment Increases CAR T Cell Cytotoxicity but Impairs Therapeutic Efficacy

This study shows that aging affects CAR T cell production and function, leading to reduced therapeutic efficacy in elderly hosts.

Overcoming the design, build, test (DBT) bottleneck for synthesis of nonrepetitive protein-RNA binding cassettes for RNA applications

The paper uses high-throughput oligo libraries and machine learning to design non-repetitive RNA binding cassettes for gene editing and RNA tracking, demonstrating their functionality in mammalian cells.

Identifying triplex binding rules in vitro leads to creation of a new synthetic regulatory tool in vivo

The paper develops a deep-sequencing platform to refine DNA triplex binding rules and creates a synthetic regulatory tool for in vivo applications.

Synthetic 5 UTRs can either up- or down-regulate expression upon RBP binding

The paper shows that synthetic 5 UTRs can be up- or down-regulated by RBP binding, revealing RNA-RBP interactions that control translation.

An in vivo binding assay for RNA-binding proteins based on repression of a reporter gene

The paper develops an in vivo method to quantify RNA-binding protein-RNA interactions using a reporter gene repression assay and SHAPE-seq in bacteria.

Improved DNA based storage capacity and fidelity using composite DNA letters

This paper introduces composite DNA alphabets to improve DNA storage capacity and fidelity by leveraging synthesis redundancy, achieving a 25% increase in storage capacity.

A synthetic oligo library and sequencing approach reveals an insulation mechanism encoded within bacterial σ54 promoters

The paper identifies an insulation mechanism in bacterial σ54 promoters using a synthetic oligo library and sequencing, showing CT-rich motifs reduce downstream gene expression.