SV40 Large T antigen inhibits the host serine protease FAM111A through a zinc-dependent, cleavage-avoiding mechanism
Allison L Welter, Sudhaker Dharavath, Yuka Machida, Julia R Alvey, Sowmiya Palani, Morgan E. Crewe, Anh T. Q. Cong, Connor P. Jewell, Kosei Iwata, Lisa M. Miller Jenkins, Matthew J. Schellenberg, Yuichi Machida
This paper identifies a zinc-dependent mechanism by which SV40 Large T antigen inhibits the host protease FAM111A to facilitate viral replication.
bioRxiv · Aug 10, 2026 · PreprintBiochemistry