Lisa M. Miller Jenkins

This study shows that 16S rRNA modification by MraW enhances translation efficiency, particularly for structured mRNAs, and that mRNA stem-loops regulate protein levels through ribosome modification.

This paper identifies a zinc-dependent mechanism by which SV40 Large T antigen inhibits the host protease FAM111A to facilitate viral replication.

The paper identifies a tumor-intrinsic immune-cloaking mechanism in neoantigen-rich cancers driven by APOBEC3 mutagenesis and 1q23.3 amplification, showing NECTIN4's role in suppressing immune responses.

The paper identifies CDK2 substrates in mouse ESCs, revealing HMCES phosphorylation's role in AP-site repair and ESC proliferation.

The paper identifies extracellular vesicles (sEVs) from EBV-transformed B-cells as a vehicle for exporting host DNA and EBV EBER1 RNA, linking peripheral EBV infection to distal tissue signaling in MS.

This study identifies SAMT-247's off-target effects on zinc-coordinating proteins in immune cells, showing increased metabolic and immune responses in stimulated THP-1 cells.

The paper identifies anti-CE1 antibodies that reduce HCC incidence and mortality by mediating NK cell ADCC against ASPH-expressing tumor cells through epitope mimicry.

This study identifies ZMAT3 as a regulator of HKDC1 transcription through JUN, suppressing mitochondrial respiration in colorectal cancer cells.

The paper identifies CNBP as a factor required for mRNA localization to cell protrusions by forming a motor-adaptor complex with KIF1C.

This study identifies FA-induced DNA-protein crosslinks (DPCs) and discovers that FEN1 repairs them via PARylation, revealing a novel PARP1-FEN1 pathway for DPC repair.

This study shows that bacterial differentiation through altruistic feeding and cell-cell signaling increases phenotypic heterogeneity, enhancing population resilience to environmental changes.

The paper identifies Smarcd1 as a 'Goldilocks' metastasis modifier gene, showing that both high and low expression correlate with better clinical outcomes, while intermediate expression worsens survival in breast cancer.

This study identifies DUXBL as a key factor promoting the silencing of the 2C transcriptional program during exit from totipotency.

This study investigates how fumarate accumulation affects RNA methylation by targeting specific 2OGDD enzymes in HLRCC cell lines, revealing differential impacts on m6A, m1A, and f5C demethylases.

cProSite provides an interactive platform for analyzing proteomics, phosphoproteomics, and genomics data from CPTAC to compare tumor and normal tissue molecular alterations.

The paper identifies a conserved SUMO-Ubiquitin pathway involving PIAS4 and RNF4 that mediates proteasomal degradation of topoisomerase DNA-protein crosslinks in human and yeast cells.