Matthew J. Schellenberg

The paper examines gene expression changes in hiPSC-derived cardiomyocytes with TOP2B deletion or treated with topobexin, showing topobexin phenocopies TOP2B knockout.

This paper identifies a zinc-dependent mechanism by which SV40 Large T antigen inhibits the host protease FAM111A to facilitate viral replication.

The paper identifies a functional regulatory circuit involving TOP2B, BARD1, and ERK2 in IEG transcription, showing how their interactions are modulated by ubiquitination and phosphorylation.

The paper shows that TOP2B and DNA-PK regulate hypoxia-inducible gene expression through DNA topology changes, with DNA-PK phosphorylating TOP2B to control its activity.

This study identifies ERK2's role in regulating TOP2B phosphorylation to facilitate transcriptional activation of immediate early genes.

This paper identifies a novel role for the BRCA1-BARD1 complex in regulating transcription by modulating topoisomerase IIβ stability and activity during gene activation.