Weak interactions drive selective proteome demixing and tune the differential response to environmental perturbations
Guido Narduzzi, Federico Zucca, Léo Willig, Ludovic C. J. Gillet, Ino D. Karemaker, Aleksander A. Rebane, Alba Tomas Sitjes, L Trevor Young, Moritz Becker, Simone Reber, Thomas C. T. Michaels, Paola Picotti, Gabriel E. Neurohr
This study introduces QuPID-MS to measure protein phase separation in cells, showing weak interactions drive proteome demixing and influence environmental response.
bioRxiv · Sep 5, 2026 · PreprintCell Biology