Gabriel E. Neurohr

This study shows that excess cell size drives senescence by altering mRNA homeostasis and reorganizing the genome, leading to the secretory phenotype and cell cycle arrest.

The paper shows that protein-driven osmotic pressure regulates nuclear size and function, affecting chromatin organization and gene expression in yeast, human, and fly cells.

This study introduces QuPID-MS to measure protein phase separation in cells, showing weak interactions drive proteome demixing and influence environmental response.

This study shows PKA regulates cytoplasmic density by controlling glycogen and trehalose, which affect diffusion and confer stress resistance.

This study expands the yeast genome with non-coding DNA and finds it reduces growth rate and endogenous mRNA concentration without affecting translation.

This study shows that non-coding DNA in yeast affects cell size and fitness by sequestering RNA polymerase, reducing transcript levels and impairing growth.

This study shows that cell wall remodeling via the CWI pathway maintains cytoplasmic crowding homeostasis during yeast cell growth.