Alzheimer's disease and its co-pathologies: implications for hippocampal degeneration, cognitive decline, and the role of APOE ϵ4
Klara Gawor, Sam Verrept, Geethika Arekatla, David Wouters, Alicja Ronisz, Moritz Hecht, Celeste Laureyssen, Helena Ver Donck, Bas Lahaije, Simona Ospitalieri, Mathieu Vandenbulcke, Markus Otto, Christine A. F. Von Arnim, Estifanos Ghebremedhin, Bernard Jimmy Hanseeuw, , Sandra O. Tomé
This study examines the interactions between A{beta}, tau, LATE-NC, -synuclein, and APOE {varepsilon}4 in 480 post-mortem brains, finding that tau is the strongest predictor of neurodegeneration while LATE-NC primarily affects hippocampal neuron loss.
Alzheimer s & Dementia · Jul 1, 2025Peer-reviewedNeuroscience