D. J. Wouters

This paper develops a modular click-chemistry strategy to modify CRISPR RNPs without disrupting their formation, enhancing DNA accessibility and enabling genome imaging.

LipoGrid quantifies lipidomic and transcriptomic changes across 143 gene knockouts, revealing gene-lipid relationships and compensatory feedback mechanisms.

SubCellSpace identifies and characterizes subcellular mRNA localization patterns in spatial transcriptomics data using a computational framework.

This paper introduces MIMA, a deep learning framework for multi-omics integration and batch correction, which effectively removes batch effects and preserves biological information across modalities.

This study examines the interactions between A{beta}, tau, LATE-NC, -synuclein, and APOE {varepsilon}4 in 480 post-mortem brains, finding that tau is the strongest predictor of neurodegeneration while LATE-NC primarily affects hippocampal neuron loss.

This study identifies two epigenetically-defined spatial niches in glioblastoma that influence cell state plasticity through local and long-range molecular signals.