Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites and pathways that regulate lifespan
Cheryl Zi Jin Phua, Xiaqing Zhao, Lesly Turcios-Hernandez, Morrigan McKernan, Morteza Abyadeh, Siming Ma, Daniel Promislow, Matt R. Kaeberlein, Alaattin Kaya
The paper investigates how knocking out nuclear-encoded mitochondrial genes in yeast affects lifespan, revealing shared mechanisms involving ribosomal proteins, actin dynamics, and proteasome function.
GeroScience · Apr 22, 2023Peer-reviewedGenetics