Author

Moustafa Gabr

Columbia University Irving Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 1

Frequent Co-Authors

Longfei ZhangiD· 3 shared Marianna Teplova· 3 shared Saurabh UpadhyayiD· 3 shared Baljit KauriD· 1 shared Laura Calvo‐BarreiroiD· 1 shared Shumayila KhaniD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

6 top collaborators · 13 mutual co-author links

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3 shared papersPharmacology & Toxicology

Longfei ZhangORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Stabilizing the CHI3L1-Gal3BP complex remodels the glioblastoma immune microenvironment and synergizes with PD-1 blockade

Saurabh Upadhyay, Longfei Zhang, Marianna Teplova, Moustafa Gabr

This study shows that stabilizing the CHI3L1-Gal3BP complex with LZ6 improves the glioblastoma immune microenvironment and extends survival, both alone and when combined with PD-1 blockade.

bioRxiv · Oct 27, 2026 · PreprintPharmacology & Toxicology

Resistance-Mutant Rescue Establishes On-Target CHI3L1 Inhibition by CHI-DEL, a Brain-Penetrant Small Molecule with In Vivo Efficacy in Glioblastoma

Saurabh Upadhyay, Longfei Zhang, Marianna Teplova, Shumayila Khan, Moustafa Gabr

The paper identifies CHI-DEL, a brain-penetrant CHI3L1 inhibitor, and validates its on-target effects using genetic rescue experiments and in vivo models of glioblastoma.

bioRxiv · Oct 24, 2026 · PreprintNeuroscience

Discovery of a brain-penetrant CHI3L1 inhibitor as an oral modulator of neuroinflammation in Alzheimers disease

Saurabh Upadhyay, Longfei Zhang, Baljit Kaur, Laura Calvo‐Barreiro, Marianna Teplova, Moustafa Gabr

This paper identifies DELC2, a brain-penetrant CHI3L1 inhibitor, which reduces neuroinflammation and amyloid-β levels in Alzheimer's disease models.

bioRxiv · Oct 21, 2026 · PreprintPharmacology & Toxicology