NeurosciencebioRxivPreprint
Resistance-Mutant Rescue Establishes On-Target CHI3L1 Inhibition by CHI-DEL, a Brain-Penetrant Small Molecule with In Vivo Efficacy in Glioblastoma
Saurabh Upadhyay, Longfei Zhang, Marianna Teplova…·Moustafa Gabr
The paper identifies CHI-DEL, a brain-penetrant CHI3L1 inhibitor, and validates its on-target effects using genetic rescue experiments and in vivo models of glioblastoma.
DOI 10.64898/2026.10.20.760326