Marianna Teplova

Oxidized TRX1 and DPP8/9 stabilize the MIA40-AIFM1 complex during intrinsic apoptosis

The paper shows that oxidized TRX1 and DPP8/9 stabilize the MIA40-AIFM1 complex during intrinsic apoptosis, promoting NLRP1 restraint and preventing pyroptosis.

Stabilizing the CHI3L1-Gal3BP complex remodels the glioblastoma immune microenvironment and synergizes with PD-1 blockade

This study shows that stabilizing the CHI3L1-Gal3BP complex with LZ6 improves the glioblastoma immune microenvironment and extends survival, both alone and when combined with PD-1 blockade.

Resistance-Mutant Rescue Establishes On-Target CHI3L1 Inhibition by CHI-DEL, a Brain-Penetrant Small Molecule with In Vivo Efficacy in Glioblastoma

The paper identifies CHI-DEL, a brain-penetrant CHI3L1 inhibitor, and validates its on-target effects using genetic rescue experiments and in vivo models of glioblastoma.

Discovery of a brain-penetrant CHI3L1 inhibitor as an oral modulator of neuroinflammation in Alzheimers disease

This paper identifies DELC2, a brain-penetrant CHI3L1 inhibitor, which reduces neuroinflammation and amyloid-β levels in Alzheimer's disease models.

A base-modifying enzyme extends the range of anti-phage defense provided by DNA glycosylases

Brig3, a DNA glycosylase from a soil metagenome, excises 5-hydroxymethylcytosine from T-even phage DNA; the glucose hydrolase BapA extends defense to glucosylated genomes such as wild-type T4.