A 36-base hairpin within lncRNA DRAIC, which is modulated by alternative splicing, interacts with the IKKα coiled-coil domain and inhibits NF-κB and tumor cell phenotypes
Xiaoxiao Hao, Yuechuan Chen, Divya Sahu, Róża K. Przanowska, Mujawar Aaiyas, Chase A. Weidmann, Isaac K. Nardi, Kevin M. Weeks, Anindya Dutta
The paper identifies a 36-base hairpin in lncRNA DRAIC that interacts with IKKα's coiled-coil domain, inhibits NF-κB activity, and suppresses tumor phenotypes through alternative splicing regulation.
Journal of Biological Chemistry · May 2, 2025Peer-reviewedMolecular Biology