Róża K. Przanowska

This study shows that tocilizumab enhances docetaxel efficacy in ER+ breast cancer by blocking IL-6/STAT3 signaling driven by pericytes and tumor cells.

OrganoSeg2 improves organoid segmentation and tracking, outperforming alternatives and enabling analysis of growth and radiotherapy responses in breast cancer organoids.

The paper identifies a 36-base hairpin in lncRNA DRAIC that interacts with IKKα's coiled-coil domain, inhibits NF-κB activity, and suppresses tumor phenotypes through alternative splicing regulation.

This study shows that primary hepatocytes can replicate DNA without ORC2, similar to cancer cell lines, by loading MCM2-7 complexes.

This study develops zero-passage organoids from luminal breast cancer patient samples to test genetic and pharmacologic perturbations, finding variable hormone responsiveness and complex interactions with sulforaphane and NQO1 knockout.

The paper identifies Twist2 as a key regulatory node in adipogenesis using kinetic networks derived from ATAC-seq and PRO-seq data.

The paper identifies distinct structural domains in the MUNC lncRNA that regulate different promyogenic genes through cis and trans mechanisms.

The paper shows that the miR-206 family is not essential for myogenesis in vitro but affects mitochondrial function and muscle performance in vivo.

The paper identifies prognostic germline variants in 10,582 cancer patients using multivariate Cox regression, showing their association with patient outcomes beyond clinical data.

The paper examines tRNA-derived fragments (tRFs) and microRNAs in the maternal-fetal interface of a mouse model to assess their expression patterns and response to maternal immune activation.