A first-in-Plasmodium study on tRNA intron splicing endonuclease PfTSEN1 and its substrate expression in clinical stage malaria
Mukesh Kumar Maurya, Ankita Behl, Amandeep Kaur Kahlon, Fernando De León, Palak Middha, Reena Nirban, Prerna Joshi, Jhalak Singhal, Geeta Kumari, Akshay Munjal, Rumaisha Shoaib, Neha Jha, Jagriti Pandey, Tanmay Dutta, Christoph Arenz, , Shailja Singh
The paper identifies PfTSEN1 as a tRNA splicing endonuclease in Plasmodium falciparum and demonstrates its inhibition by TSENi, a novel anti-malarial compound.
bioRxiv · Jun 7, 2024 · PreprintMolecular Biology