Christoph Arenz

This paper identifies KPB82 as a potent and selective ACER2 inhibitor that reduces doxorubicin-induced cytotoxicity in multiple cell types.

This study identifies a rapid host cell entry pathway for Staphylococcus aureus that influences intracellular fate, leading to different replication rates and host cell death compared to slower pathways.

This paper improves synthetic transcription factors in yeast to enhance production of 3'-phosphoadenosine-5'-phosphosulfate (PAPS) through engineered loop flexibility and stability.

This study identifies CYP4F2 as a key enzyme mediating ω-hydroxylation of 1-deoxySLs, revealing a new hepatic detoxification pathway that reduces their cytotoxicity.

This study identifies SPTLC3's role in integrating bile acid-FXR signaling with sphingolipid remodeling in MASLD, showing its dysregulation in human liver and association with disease.

The paper assesses the functional relevance of a Plasmodium MFS protein as a drug transporter using Candida glabrata, showing antifungal resistance and antimalarial properties.

The paper identifies PfTSEN1 as a tRNA splicing endonuclease in Plasmodium falciparum and demonstrates its inhibition by TSENi, a novel anti-malarial compound.

This study identifies a cold shock protein in Plasmodium falciparum essential for asexual and sexual stages and shows its potential as a druggable target.