Nucleolin is expressed in human fetal brain development and reactivated in human glial brain tumors regulating angiogenesis and vascular metabolism
Marc Schwab, Ignazio de Trizio, Jau-Ye Shiu, Moheb Ghobrial, Oǧuzkan Sürücü, Francesco Girolamo, Mariella Errede, Murat Yilmaz, Johannes Haybaeck, Alessandro Moiraghi, Philippe Patrick Monnier, Sean Edward Lawler, Jeffrey Peter Greenfield, Ivan Radovanovic, Karl Frei, , Thomas Wälchli
This study identifies Nucleolin as a factor reactivated in gliomas that promotes angiogenesis and endothelial metabolism by regulating glycolysis through p53-TIGAR-HK2.
bioRxiv · Oct 14, 2020 · PreprintNeuroscience