Philippe Patrick Monnier

Unbiased Long-Read Whole-Genome Sequencing Enables High-Resolution Mapping of Transgene Concatenation and Off-target Genomic Disruption in a Mouse Model

The paper uses long-read sequencing to detect transgene concatenation and off-target integration in a mouse model, revealing hidden genomic complexity and phenotypic disruption.

Segregated localization of target-SNARE proteins within presynaptic terminals of Munc18-1 deficient photoreceptors

The paper investigates the localization of SNARE proteins in Munc18-1 deficient photoreceptors and finds that Munc18-1 prevents segregation of syntaxin-3 and SNAP-25 in presynaptic terminals.

Onco-fetal protein Nogo-A restricts human and mouse glioma vascularization and growth via VEGF-Notch-hippo-metabolic signaling

This study identifies Nogo-A as an onco-fetal protein that inhibits glioma vascularization and growth through VEGF-Notch-Hippo-metabolic signaling in human and mouse models.

Parkinsons Disease Pathology is Directly Correlated to SIRT3 in Human Subjects and Animal Models: Implications for AAV.SIRT3-myc as a Disease-Modifying Therapy.

This paper shows SIRT3 levels decrease with age and in Parkinson's disease, and over-expression of SIRT3 reduces α-synuclein aggregation, supporting AAV.SIRT3-myc as a potential therapy.

SNAP-25, but not SNAP-23, is essential for photoreceptor function and survival in mice

Mouse model of multiple sclerosis induced by disrupting vesicular transport in oligodendrocytes

This study shows that disrupting vesicular transport in adult oligodendrocytes causes demyelination and neuroinflammation, contributing to Multiple Sclerosis.

Double mutation of open syntaxin and UNC-18 P334A leads to excitatory-inhibitory imbalance and impairs multiple aspects of C. elegans behavior

The paper investigates the combined effects of two exocytosis-enhancing mutations in C. elegans and finds they disrupt excitatory-inhibitory balance and impair multiple behaviors.

Neuronal SNAP-23 scales hippocampal synaptic plasticity and memory

This study shows that neuronal SNAP-23 is essential for hippocampal synaptic plasticity and spatial memory but not for basal glutamate receptor function.

Molecular atlas of the human brain vasculature at the single-cell level

The paper constructs a molecular atlas of the human brain vasculature using single-cell RNA sequencing, revealing molecular heterogeneity and disease-related alterations in vascular cells.

Hierarchical imaging and computational analysis of three-dimensional vascular network architecture in the entire postnatal and adult mouse brain

This paper describes a method to image and analyze 3D vascular networks in mouse brains across development and adulthood, quantifying various vascular features.

Open syntaxin overcomes synaptic transmission defects in diverse C. elegans exocytosis mutants

This study shows that overexpressing an open form of syntaxin can rescue exocytosis defects in multiple C. elegans mutants, suggesting a general mechanism to enhance synaptic transmission.

Nucleolin is expressed in human fetal brain development and reactivated in human glial brain tumors regulating angiogenesis and vascular metabolism

This study identifies Nucleolin as a factor reactivated in gliomas that promotes angiogenesis and endothelial metabolism by regulating glycolysis through p53-TIGAR-HK2.

The human brain vasculature shows a distinct expression pattern of SARS-CoV-2 entry factors

The paper constructs a single-cell atlas of SARS-CoV-2 entry factors and interaction partners in human and mouse brain vasculature, revealing distinct expression patterns of CTSB and CTSL in brain and peripheral vasculature.